Tissue-specific genetic interactions drive different types of cancer development

By | July 19, 2021
Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium, the Technical University of Munich, and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in precursor cells of the pancreas or the bile duct leads to fundamental different outcomes.